Michigan State Police said two children died in a house fire early Monday in Constantine Township.
Troopers and fire personnel responded around 12:30 a.m. to a location in the 14000 block of Timm Road. Authorities said the fire claimed the lives of a 4-year-old boy and 3-year-old girl.
By the time authorities arrived on the scene, the home was fully engulfed in flames.
Cause of the blaze has not been determined. Investigators and local fire departments worked through the night to piece together clues.
St. Joseph County United Way has set up a donation fund to assist the family. Executive Director Kelly Hostetler said 100 percent of money raised will go to funeral expenses, and gift cards for food and clothing. More information is available on the United Way website or by calling its Centreville office, 467-9099.